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Jun-Ichi Hayashi Selected Research

Leu Transfer RNA

11/2015Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.
2/2014Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene.

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Jun-Ichi Hayashi Research Topics

Disease

29Mitochondrial Diseases (Mitochondrial Disease)
02/2022 - 04/2002
22Neoplasms (Cancer)
11/2017 - 02/2005
11Neoplasm Metastasis (Metastasis)
11/2017 - 05/2008
7Carcinoma (Carcinomatosis)
01/2016 - 10/2008
4Premature Aging
11/2018 - 01/2013
3Lymphoma (Lymphomas)
01/2015 - 06/2012
3Adenocarcinoma
01/2015 - 08/2008
3Hypoxia (Hypoxemia)
11/2013 - 09/2002
3Male Infertility (Male Sterility)
01/2011 - 10/2006
2Osteoporosis
11/2018 - 01/2015
2Cardiomyopathies (Cardiomyopathy)
04/2017 - 08/2015
2VLCAD deficiency
09/2013 - 05/2007
2Lewis Lung Carcinoma
01/2013 - 11/2009
2Carcinogenesis
12/2012 - 01/2009
2Body Weight (Weight, Body)
01/2011 - 11/2008
2Deafness (Deaf Mutism)
01/2011 - 11/2008
2Lactic Acidosis
01/2011 - 11/2008
2Muscular Diseases (Myopathy)
01/2011 - 11/2008
2Renal Insufficiency (Renal Failure)
01/2011 - 11/2008
2Ischemia
01/2011 - 11/2008
2Lung Neoplasms (Lung Cancer)
04/2009 - 08/2008
1Wounds and Injuries (Trauma)
02/2022
1Proteinuria
02/2022
1Hyperparathyroidism
11/2018
1Propofol Infusion Syndrome
01/2018
1Infections
11/2017
1Bacterial Infections (Bacterial Infection)
11/2017
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
04/2017
1MELAS Syndrome (Syndrome, MELAS)
11/2015
1Muscle Weakness
03/2015
1Late Onset Disorders
03/2015
1Hyperlipidemias (Hyperlipidemia)
02/2015
1Animal Disease Models
02/2015
1Hyperglycemia
02/2015
1Weight Gain
02/2015
1Glucose Intolerance
02/2015
1Muscular Atrophy (Muscle Atrophy)
01/2015
1Hepatocellular Carcinoma (Hepatoma)
01/2015
1Adenoma (Adenomas)
01/2015
1Leigh Disease (Leigh's Disease)
05/2014
1Sideroblastic Anemia
09/2013
1Kearns-Sayre Syndrome
09/2013
1Alopecia (Baldness)
01/2013
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2013
1Kyphosis
01/2013
1Nervous System Diseases (Neurological Disorders)
04/2012
1Heart Block
01/2011
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2011
1Cognitive Dysfunction
12/2008
1Wolf-Hirschhorn Syndrome
08/2008
1Anemia
05/2007
1Type 2 Diabetes Mellitus (MODY)
11/2006
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
11/2006
1Interstitial Lung Diseases (Interstitial Lung Disease)
01/2006

Drug/Important Bio-Agent (IBA)

49Mitochondrial DNA (mtDNA)IBA
02/2022 - 04/2002
9Reactive Oxygen Species (Oxygen Radicals)IBA
11/2017 - 09/2008
9DNA (Deoxyribonucleic Acid)IBA
11/2017 - 02/2005
3EnzymesIBA
05/2014 - 04/2009
3Proteins (Proteins, Gene)FDA Link
11/2009 - 08/2008
2NADH DehydrogenaseIBA
11/2017 - 11/2006
2Leu Transfer RNAIBA
11/2015 - 02/2014
2Lys Transfer RNAIBA
03/2015 - 02/2014
2LigandsIBA
02/2015 - 01/2014
2Lactic Acid (Lactate)FDA LinkGeneric
09/2010 - 08/2010
2Messenger RNA (mRNA)IBA
11/2009 - 04/2009
2Indicators and Reagents (Reagents)IBA
01/2006 - 02/2004
1Aeromonas hydrophilia lipase-acyltransferase (GCAT)IBA
11/2018
1Parathyroid Hormone (Parathormone)IBA
11/2018
1Phenformin (Fenformin)IBA
01/2018
1CaspasesIBA
01/2018
1BiguanidesIBA
01/2018
1Propofol (Diprivan)FDA LinkGeneric
01/2018
1Metformin (Glucophage)FDA LinkGeneric
01/2018
1NucleotidesIBA
11/2017
1C 39 (C39)IBA
04/2017
1Pioglitazone (Actos)FDA Link
02/2015
1Glucose (Dextrose)FDA LinkGeneric
02/2015
1ethyl 4- (3- (3,5- dichlorophenyl)thioureido)piperidine- 1- carboxylateIBA
02/2015
1AntioxidantsIBA
01/2014
1Acetylcysteine (Siran)FDA LinkGeneric
01/2014
1IronIBA
09/2013
1Peptides (Polypeptides)IBA
01/2013
1Interleukin-6 (Interleukin 6)IBA
01/2013
1LactatesIBA
06/2012
1CalciumIBA
04/2012
1mitochondrial transcription factor AIBA
10/2010
1Electron Transport Complex I (NADH-CoQ Reductase)IBA
09/2010
1Histone Deacetylases (Histone Deacetylase)IBA
11/2009
1Protein Kinase CIBA
11/2009
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
11/2009
1Fluorouracil (Carac)FDA LinkGeneric
04/2009
1Proline (L-Proline)FDA Link
11/2006
1Amino AcidsFDA Link
11/2006
1Serine (L-Serine)FDA Link
11/2006
1CarcinogensIBA
02/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2002

Therapy/Procedure

5Transplantation
10/2010 - 11/2005
4Therapeutics
01/2014 - 01/2008
1Segmental Mastectomy (Lumpectomy)
08/2008
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
06/2006